Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging
Identifieur interne : 001699 ( Main/Exploration ); précédent : 001698; suivant : 001700Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging
Auteurs : Zang-Hee Cho [Corée du Sud] ; Se-Hong Oh [Corée du Sud] ; Jong-Min Kim [Corée du Sud] ; Sung-Yeon Park [Corée du Sud] ; Dae-Hyuk Kwon [Corée du Sud] ; Hye-Jin Jeong [Corée du Sud] ; Young-Bo Kim [Corée du Sud] ; Je-Geun Chi [Corée du Sud] ; Chan-Woong Park [Corée du Sud] ; John Huston Iii [États-Unis] ; Kendall H. Lee [États-Unis] ; Beom S. Jeon [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- 7.0T MRI, Adult, Aged, Brain Mapping, Case-Control Studies, Encephalon, Female, Functional Laterality, Human, Humans, Image Processing, Computer-Assisted (methods), Locus niger, Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Substantia Nigra (pathology), Visualization, brain imaging, neurodegenerative disorder, substantia nigra.
- MESH :
- methods : Image Processing, Computer-Assisted.
- pathology : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Brain Mapping, Case-Control Studies, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age‐matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean “arch” shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch‐like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age‐dependent correlation and substantially stronger UPDRS motor score‐dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23465
Affiliations:
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Eon" sort="Park, Sung Eon" uniqKey="Park S" first="Sung-Yeon" last="Park">Sung-Yeon Park</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Dae Yuk" sort="Kwon, Dae Yuk" uniqKey="Kwon D" first="Dae-Hyuk" last="Kwon">Dae-Hyuk Kwon</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, Hye In" sort="Jeong, Hye In" uniqKey="Jeong H" first="Hye-Jin" last="Jeong">Hye-Jin Jeong</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Young O" sort="Kim, Young O" uniqKey="Kim Y" first="Young-Bo" last="Kim">Young-Bo Kim</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Chi, Je Eun" sort="Chi, Je Eun" uniqKey="Chi J" first="Je-Geun" last="Chi">Je-Geun Chi</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Park, Chan Oong" sort="Park, Chan Oong" uniqKey="Park C" first="Chan-Woong" last="Park">Chan-Woong Park</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Huston Iii, John" sort="Huston Iii, John" uniqKey="Huston Iii J" first="John" last="Huston Iii">John Huston Iii</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Lee, Kendall H" sort="Lee, Kendall H" uniqKey="Lee K" first="Kendall H." last="Lee">Kendall H. Lee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name><affiliation wicri:level="4"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="713">713</biblScope><biblScope unit="page" to="718">718</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2883EE4D136531306021AE456BFFF705B1FA6953</idno><idno type="DOI">10.1002/mds.23465</idno><idno type="ArticleID">MDS23465</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>7.0T MRI</term><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Encephalon</term><term>Female</term><term>Functional Laterality</term><term>Human</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Locus niger</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Substantia Nigra (pathology)</term><term>Visualization</term><term>brain imaging</term><term>neurodegenerative disorder</term><term>substantia nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Homme</term><term>Imagerie RMN</term><term>Locus niger</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Visualisation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age‐matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean “arch” shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch‐like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age‐dependent correlation and substantially stronger UPDRS motor score‐dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Minnesota</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Cho, Zang Ee" sort="Cho, Zang Ee" uniqKey="Cho Z" first="Zang-Hee" last="Cho">Zang-Hee Cho</name></noRegion><name sortKey="Chi, Je Eun" sort="Chi, Je Eun" uniqKey="Chi J" first="Je-Geun" last="Chi">Je-Geun Chi</name><name sortKey="Chi, Je Eun" sort="Chi, Je Eun" uniqKey="Chi J" first="Je-Geun" last="Chi">Je-Geun Chi</name><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name><name sortKey="Jeong, Hye In" sort="Jeong, Hye In" uniqKey="Jeong H" first="Hye-Jin" last="Jeong">Hye-Jin Jeong</name><name sortKey="Kim, Jong In" sort="Kim, Jong In" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name><name sortKey="Kim, Young O" sort="Kim, Young O" uniqKey="Kim Y" first="Young-Bo" last="Kim">Young-Bo Kim</name><name sortKey="Kwon, Dae Yuk" sort="Kwon, Dae Yuk" uniqKey="Kwon D" first="Dae-Hyuk" last="Kwon">Dae-Hyuk Kwon</name><name sortKey="Oh, Se Ong" sort="Oh, Se Ong" uniqKey="Oh S" first="Se-Hong" last="Oh">Se-Hong Oh</name><name sortKey="Park, Chan Oong" sort="Park, Chan Oong" uniqKey="Park C" first="Chan-Woong" last="Park">Chan-Woong Park</name><name sortKey="Park, Sung Eon" sort="Park, Sung Eon" uniqKey="Park S" first="Sung-Yeon" last="Park">Sung-Yeon Park</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Huston Iii, John" sort="Huston Iii, John" uniqKey="Huston Iii J" first="John" last="Huston Iii">John Huston Iii</name></region><name sortKey="Lee, Kendall H" sort="Lee, Kendall H" uniqKey="Lee K" first="Kendall H." last="Lee">Kendall H. 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